J Clin Pathol. 1986 Aug. 154(2):373-4. Typhoid fever is treated with antibiotics that kill the bacteria. [Medline]. [Medline]. Cavallaro E, Date K, Medus C, Meyer S, Miller B, Kim C, et al. Dashti AA, Jadaon MM, Habeeb F, West PW, Panigrahi D, Amyes SG. J Antimicrob Chemother. 1978 Mar. Hornick RB, Griesman S. On the pathogenesis of typhoid fever. 1999. 49(47):1975-6. Polish Typhoid Committee. 1992 Jun. The complications of typhoid fever. Thomas Garvey, MD, JD is a member of the following medical societies: American College of Legal Medicine, American College of Physicians, American Society of Law, Medicine & EthicsDisclosure: Nothing to disclose. 1993 Jul. Typhoid fever: pathogenesis and immunologic control. Lancet. 75:214-7. http://www.cdc.gov/narms/pdf/2012-annual-report-narms-508c.pdf, American Society of Law, Medicine & Ethics, Southern Society for Clinical Investigation. Mermin J, Hutwagner L, Vugia D, et al. 366:749-62. [Medline]. 1982 Nov-Dec. 4(6):1096-106. 1993 Jan 2. 136(4):436-48. Other symptoms of typhoid fever and paratyphoid fever include. MMWR. 1999. Estimate of illnesses from Salmonella enteritidis in eggs, United States, 2000. 1991 Mar. JAMA. Murray PR, Baron EJ, Pfaller MA, eds. Antimicrob Agents Chemother. 2008 Apr. Mandal BK. Microbes Infect. Mary D Nettleman, MD, MS, MACP is a member of the following medical societies: American College of Physicians, Association of Professors of Medicine, Central Society for Clinical and Translational Research, Infectious Diseases Society of America, Society of General Internal MedicineDisclosure: Nothing to disclose. Pediatr Infect Dis J. [Medline]. Gordon MA. Cryz SJ Jr. Post-marketing experience with live oral Ty21a vaccine. Multiple brain abscesses caused by Salmonella typhi: case report. [Medline]. World Health Organization Communicable Disease Surveilance and Response. Do not prepare or serve food for other people. 6th ed. 67 (3):75-80. Am J Trop Med Hyg. Rev Infect Dis. 2017 Nov 1. Principles and Practices of Infectious Diseases. [Medline]. Mani V, Brennand J, Mandal BK. [Medline]. Found inside – Page 152Regardless of the accuracy of this speculation, we do know that typhoid has tended to disappear in those countries where mass mechanisms of spread have been ... Typhoid fever was diagnosed by clinical criteria and/or positive blood culture at 2 weeks in 77% of controls (n=31) as compared to 35% in the Vi-TT group (n=37) to give vaccine efficacy of 54% (95% confidence interval of 26-71). [Medline]. Found insideShows how the investigation of local outbreaks of typhoid fever in Victorian Britain led to the emergence of the modern discipline of epidemiology as the leading science of public health 283(13):686-91. 1997. 2015 Sep 28. Typhoid fever. 2002 Nov 28. 1989 Apr. Pithie AD, Wood MJ. Antimicrob Agents Chemother. Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food--10 states, 2007. [Medline]. Ann Intern Med. Fraser A, Goldberg E, Acosta CJ, Paul M, Leibovici L. Vaccines for preventing typhoid fever. Several antibiotics are effective for the treatment of typhoid fever. [Medline]. Bull World Health Organ. Hoffman SL, Edman DC, Punjabi NH, et al. Mark R Wallace, MD, FACP, FIDSA Infectious Disease Physician, Skagit Valley Hospital, Skagit Regional HealthDisclosure: Nothing to disclose. MMWR Morb Mortal Wkly Rep. 2003 Dec 12. Rose spots on abdomen of a patient with typhoid fever due to the bacterium Salmonella typhi. Clin Infect Dis. 1946. Infected (mycotic) aneurysms: spectrum of imaging appearances and management. Persistent fever develops and gradually rises, usually in a stepwise fashion, reaching a peak of 39 or 40 °C … Scully BE, Nakatomi M, Ores C, et al. Dutta S, Sur D, Manna B, Bhattacharya SK, Deen JL, Clemens JD. 49(4):1662-3. 302(8):859-65. Emergence of domestically acquired ceftriaxone-resistant Salmonella infections associated with AmpC beta-lactamase. Use of norfloxacin to treat chronic typhoid carriers. Song predicts that the information obtained from this study would serve as a basis for future typhoid toxin-neutralizing strategies that would be most effective when combined with anti-bacterial … Cell Host Microbe. [Medline]. Bodhidatta L, Taylor DN, Thisyakorn U, et al. Host-pathogen interaction in invasive Salmonellosis. 1975 May 31. Clin Infect Dis. 1;56(3):121-2. Yanagi D, de Vries GC, Rahardjo D, Alimsardjono L, Wasito EB, De I, et al. Leavitt's, Typhoid Mary, is a rigorous historical analysis of "Typhoid Mary". 56(6):413-22. 25:185-98. [Medline]. N Engl J Med. Again, this is nonspecific and insensitive for the diagnosis. [Medline]. Clin Infect Dis. 1975 Sep. 83(3):432. Most kids start feeling better within 2 to 3 days of beginning treatment. 37 (2):123-8. Cochrane Database Syst Rev. Centers for Disease Control and Prevention (CDC). Typhoid Vaccine Acceleration Consortium (TyVAC) The Typhoid Vaccine Acceleration Consortium (TyVAC), a partnership between the Center for Vaccine Development at the University of Maryland School of Medicine, the Oxford Vaccine Group at the University of Oxford, and PATH, an international nonprofit, aims to accelerate the introduction of new typhoid conjugate vaccines … 2008 Jan. 24(1):22-6. Pai H, Byeon JH, Yu S, Lee BK, Kim S. Salmonella enterica serovar typhi strains isolated in Korea containing a multidrug resistance class 1 integron. Typhoid Fever Vaccine. But, researchers from the University of Liverpool and Liverpool School of Tropical Medicine wanted to know if the vaccine could do more. 2004 May. CDC twenty four seven. Acharya IL, Lowe CU, Thapa R, et al. Found inside – Page ivThe book includes a section on the basic principles of immunology, and then applies them to particular examples of disease in human populations. The target audience for this text book are Masters of Public Health students. 1989. [Medline]. Effa EE, Lassi ZS, Critchley JA, et al. While it may be admitted that spontaneous recovery takes place after intestinal perforation in the course of typhoid fever, such an event certainly is exceedingly uncommon. Infect Genet Evol. Nunes AP, Marques A, Marchado C, Meirelaes N, Sobrinho G, et al. It provides protection for up to five years and is approved for use in individuals over six years old. Crump JA, Medalla FM, Joyce KW, Krueger AL, Hoekstra RM, Whichard JM, et al. Mandell, et al, ed. Cell Microbiol. Fuchs J, Podda M, eds. Sometimes, the disease will go away on its own, but it can last for weeks or months without treatment: Your treatment plan will involve a course … The clinical course of typhoid fever varies greatly, ranging from fever with little other morbidity to marked multisystem toxemia. 58(2):112-8. 1989 Jun. Su LH, Chiu CH. When she wasn’t coaxing Typhoid Mary to get tested, Dr. Sara Josephine Baker focused most of her career on lowering infant mortality rates in the poorest parts of New York City. Epidemiol Infect. Dr. Jeongmin Song, associate professor of microbiology and immunology, has published a recent study in iScience that details new typhoid toxin-neutralizing antibodies. Neuropsychiatric manifestations of typhoid fever in 959 patients. Most patients have high fevers, generalized fatigue, headache, and loss of appetite. Evaluating candidate agents of selective pressure for cystic fibrosis. [Medline]. Typhoid fever in present-day Britain. Bone marrow aspirate culture superior to streptokinase clot culture and 8 ml 1:10 blood-to-broth ratio blood culture for diagnosis of typhoid fever. Delirium/hallucinations. ... the father initiated a 10-day course of amoxicillin using an … 1(7918):1211-3. If you stop it too soon, some bacteria could remain. Scand J Gastroenterol Suppl. 1976. 73:146-61. Arch Neurol. Rose spots in shigellosis caused by Shigella dysenteriae type 1 infection. Spanò S, Ugalde JE, Galán JE. 2012 Apr. Bitar R, Tarpley J. Intestinal perforation in typhoid fever: a historical and state-of-the-art review. Chest. [Medline]. 1990 Nov. 66(781):923-5. Christie AB. 2018 Nov 10. J Pediatr. Typhoid fever is one of the major causes of mortality and morbidity in overcrowded and unhygienic areas though comprehensive research and public health interventions have decreased the occurrence. Salmonella infections. J Immunol. 1969 Aug 2. Tiphymurium Salmonella Aortitis. J Immunol. If you are being treated for typhoid fever or paratyphoid fever, it is important to do the following to lower the chance that you will pass the bacteria on to someone else. Mechanisms of Salmonella entry into host cells. From the Centers for Disease Control and Prevention. Comparative yield of Salmonella typhi from blood and bone marrow cultures in patients with fever of unknown origin. Clin Infect Dis. Severe headache. In many cases, typhoid fever is treated with ampicillin, chloramphenicol, or cotrimoxazole (Bactrim®). Hornick RB, Greisman SE, Woodward TE, et al. 82(5):346-53. Typhoid fever in children aged less than 5 years. A note on incidence of typhoid fever in diverse age groups in Kolkata, India. Typhoid [Medline]. Tropical Infectious Diseases: Principles, Pathogens, and Practice. N Engl J Med. 2006 Jun. Br Med J. [Medline]. J Infect Dis. [Medline]. Antimicrob Agents Chemother. This website also contains material copyrighted by 3rd parties. Br Med J. Frenck RW Jr, Nakhla I, Sultan Y, Bassily SB, Girgis YF, David J, et al. Lancet Infect Dis. Laboratory-based surveillance of Salmonella serotype Typhi infections in the United States: antimicrobial resistance on the rise. Cooke FJ, Wain J. Immunogenicity and protective efficacy of Vi vaccine against typhoid fever three years after immunization (abstract). Detection of decreased fluoroquinolone susceptibility in Sal.onella and validation of nalidixic acid screening test. 2008 Dec 1. Azithromycin versus ceftriaxone for the treatment of uncomplicated typhoid fever in children. Background document: The diagnosis, treatment and prevention of typhoid fever. This 2020 edition includes: · Country-specific risk guidelines for yellow fever and malaria, including expert recommendations and 26 detailed, country-level maps · Detailed maps showing distribution of travel-related illnesses, including ... Salmonella infections in immunocompromised adults. a bacterial infection transmitted by ingesting food and water that is contaminated with Salmonella typhi. Michael Stuart Bronze, MD David Ross Boyd Professor and Chairman, Department of Medicine, Stewart G Wolf Endowed Chair in Internal Medicine, Department of Medicine, University of Oklahoma Health Science Center; Master of the American College of Physicians; Fellow, Infectious Diseases Society of America; Fellow of the Royal College of Physicians, London [Medline]. Arch Intern Med. To protect the public's health, authorities isolated her on Manhattan's North Brother Island, where she died some thirty years later. This book tells the remarkable story of Mary Mallon—the real Typhoid Mary. 8 (6):e2925. Found inside – Page 403Louis had shown that the course of typhoid fever could neither be interrupted nor shortened by treatment, and his conclusion was supported by the earlier ... List of drugs used to treat the medical condition called Typhoid and Paratyphoid Enteric Fevers. Relative efficacy of blood, urine, rectal swab, bone-marrow, and rose-spot cultures for recovery of Salmonella typhi in typhoid fever. MMWR Morb Mortal Wkly Rep. 2015 Mar 27. [Medline]. Serodiagnosis of typhoid fever by enzyme-linked immunosorbent assay determination of anti-Salmonella typhi lipopolysaccharide antibodies. [Medline]. Hohmann EL. Ahmed D, D'Costa LT, Alam K, Nair GB, Hossain MA. 5th ed. Ikejiri K, Suzuki K, Ito A, Yasuda K, Shindo A, Ishikura K, et al. [Medline]. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cDovL3d3dy5tZWRzY2FwZS5jb20vYW5zd2Vycy8yMjgxNzQtNzc1MDYvd2hhdC1pcy10aGUtY2xpbmljYWwtY291cnNlLW9mLXR5cGhvaWQtZmV2ZXItaW4tc2FsbW9uZWxsb3Npcw==. [Medline]. 354(9180):734-7. Mymensingh Med J. Oral Typhoid Vaccine Salmonella typhi strain Ty21a (live, attenuated).. 2 Qualitative and Quantitative Composition. 2004 Feb. 7(1):78-84. Breakey WR, Kala AK. J Infect. Eur Radiol. 79(3):222-9. Gupta A. Multidrug-resistant typhoid fever in children: epidemiology and therapeutic approach. [Medline]. Farid Z, Higashi GI, Bassily S, et al. Pakistan’s current extensively drug resistant (XDR) outbreak of typhoid, which has infected more than 10 000 people, mostly in Sindh province, is the first-ever reported outbreak of typhoid … [Medline]. [Medline]. Follow the links to read common uses, side effects, dosage details and … [Medline]. Risk factors for typhoid in Darjeeling, West Bengal, India: evidence for practical action. [Medline]. Stoleru GH, Le Minor L, Lheritier AM. Rowland HA. [Medline]. Rubin FA, McWhirter PD, Punjabi NH, et al. Bacteriophage application on red meats and poultry: Effects on Salmonella population in final ground products. Typhoid catatonia responsive to ECT. JAMA. Steven K Schmitt, MD is a member of the following medical societies: Infectious Diseases Society of AmericaDisclosure: Nothing to disclose. 1975 May 31. Djemgou PC, Gatsing D, Hegazy ME, El-Hamd Mohamed AH, Ngandeu F, Tane P, et al. Clin Exp Immunol. J Clin Microbiol. Hakanen A, Kotilanien P, Jalava J, et al. 1990 Dec. 26 Suppl F:47-53. [Medline]. Akalin HE. Molecular analysis of multi-drug resistant Salmonella typhi from urban paediatric population of Bangladesh. If the condition is detected early, disease is usually mild and most cases can be treated with a … Pancreatic disturbances and typhoid fever. Sharma PK, Ramakrishnan R, Hutin Y, et al. Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug ReferenceDisclosure: Received salary from Medscape for employment. Host-Salmonella interaction: human trials. [Medline]. Clin Infect Dis. [Medline]. Jackson BR, Iqbal S, Mahon B. 1974 Jan. 88(2):71-8. [Medline]. [Medline]. Following things would help you 1) drink plenty of fluids as fever due to typhoid causes dehydration. 333(7558):78-82. Am J Gastroenterol. 338:b1865. [Medline]. Duodenal string-capsule culture compared with bone-marrow, blood, and rectal-swab cultures for diagnosing typhoid and paratyphoid fever. Infectious Diseases. Trans R Soc Trop Med Hyg. Typhoid fever is caused by a bacterium, Salmonella typhi. [Medline]. Rev Port Cir Cardiotorac Vasc. Rev Infect Dis. Murray PR, Baron EF, Pfaller MA, eds. Rev Infect Dis. [Medline]. 1975 Jul. Notes from the field: Human Salmonella infantis infections linked to dry dog food--United States and Canada, 2012. Weight loss and debilitating weakness last months. [Medline]. Pulmonary manifestations of multidrug-resistant typhoid fever. A study of typhoid fever in five Asian countries: disease burden and implications for controls. J Antimicrob Chemother. JAMA. 127(4):477-86. 2015 Mar 21. Sur D, Ochiai RL, Bhattacharya SK, Ganguly NK, Ali M, Manna B, et al. The Bare Facts. [Medline]. 2018 Apr. 169:19-23. Huckstep RL. Papagrigorakis MJ, Synodinos PN, Yapijakis C. Ancient typhoid epidemic reveals possible ancestral strain of Salmonella enterica serovar Typhi. Infection. Reexamination of the protective role of the capsular polysaccharide (Vi antigen) of Salmonella typhi. Risk factors for typhoid and paratyphoid fever in Jakarta, Indonesia. CRC Press; 2004. Short course of ofloxacin for treatment of multidrug-resistant typhoid. Epidemiological and Clinical Aspects of Typhoid Fever. Microbiol Immunol. [Medline]. Edinburgh, Scotland: Churchill Livingstone; 1962. Salmonella typhimurium infections associated with peanut products. Typhoid fever results from infection with a bacterium called Salmonella Typhi and is a major cause of illness worldwide. Ly KT, Casanova JE. Treatment of enteric fever. Typhoid Vi: a less reactogenic vaccine. Typhoid fever is a potentially deadly disease. 2008 Jan 17. 169(4):2196-203. Infectious Diseases: Epidemiology and Clinical Practice. Your doctor may order special tests to see if the bacteria causing your infection are resistant. Hoffman SL, Punjabi NH, Rockhill RC, et al. [Medline]. Clinical and serological responses following primary and booster immunization with Salmonella typhi Vi capsular polysaccharide vaccines. Extremely swollen abdomen. [Medline]. 2010 Feb. 76(2):165-71. [Medline]. 1986 May-Jun. Michael Stuart Bronze, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Medical Association, Association of Professors of Medicine, Infectious Diseases Society of America, Oklahoma State Medical Association, Southern Society for Clinical InvestigationDisclosure: Nothing to disclose. Tran TH, Bethell DB, Nguyen TT, et al. MMWR Morb Mortal Wkly Rep. 2001 Aug 24. Accessed: 10/29/08. 1975 Sep. 24(5):860-5. 849-63. [Medline]. [Medline]. 274(4):294. Typhoid fever and paratyphoid fever are treated with antibiotics. [Full Text]. Genetic exchange in Salmonella. Cochrane Database Syst Rev. Results from those tests may affect what antibiotic treatment you receive. Hermans P, Gerard M, van Laethem Y, et al. Control of clinical manifestations with cortisone. Lesser, CF, Miller, SI. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cDovL3d3dy5tZWRzY2FwZS5jb20vYW5zd2Vycy8yMzExMzUtMTA1OTEvd2hhdC1pcy10aGUtY2xpbmljYWwtY291cnNlLW9mLXR5cGhvaWQtZmV2ZXItZW50ZXJpYy1mZXZlci1hZnRlci0zLXdlZWtz. Salmonella Typhi is a human host-restricted pathogen that is responsible for typhoid fever in approximately 10.9 million people annually 1.The typhoid toxin is postulated to have a central role in disease pathogenesis, the establishment of chronic infection and human host restriction 2–6.However, its precise role in typhoid disease in humans is not fully defined. These medications kill the bacteria that cause the infection. 2008 Jun. Manfredi R, Chiodo F. Salmonella typhi disease in HIV-infected patients: case reports and literature review. 4th ed. Typhoid fever can be successfully treated with an appropriate course of antibiotics. [Medline]. 2013 Aug. 81(8):2920-30. N Engl J Med. May 2004. [Full Text]. Br Med J. The clinical course of typhoid fever varies greatly, ranging from fever with little other morbidity to marked multisystem toxemia. J Bacteriol. 1970 Oct 1. Thielman, NM, Guerrant, RL. [Medline]. Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). Pediatr Infect Dis J. 8(10):e1002933. 2019 Mar 7. [Medline]. 2003 Mar 1. 82 (5):346-53. The disease is spread by ingestion of contaminated food or water. 157(6):1221-5. Antimicrob Agents Chemother. Nat Rev Microbiol. Encyclopedia of Medical Genomics and Proteomics. 2000. Antibiotics are used to treat typhoid fever. Children aged ≥6 years and adults who received oral typhoid vaccine for their 1st vaccination are recommended to receive a repeat 3- or 4-dose course of oral typhoid vaccine either: 3 years after a 3-dose course, or; 5 years after a 4-dose course 361(4):335-44. 333:78-82. May/1996. 93(6):1001-3. In conclusion, typhoid is one of the many bacterial infectious diseases capable of wreaking. [Medline]. Antimicrobial resistance in typhoidal and nontyphoidal salmonellae. Soe GB, Overturf GD. 2019 Mar. [Medline]. 1(5956):494-5. [Medline]. Robbins JD, Robbins JB. Prev Vet Med. 283(20):2668-73. Antimicrob Agents Chemother. [Medline]. Epidemics of invasive Salmonella enterica serovar enteritidis and S. enterica Serovar typhimurium infection associated with multidrug resistance among adults and children in Malawi. Rollback of Salmonella enterica serotype Typhi resistance to chloramphenicol and other antimicrobials in Kolkata, India. Williams S, Markey P, Harlock M, Binns P, Gaggin J, Patel M. Individual and household-level risk factors for sporadic salmonellosis in children. Thomas Garvey, MD, JD Primary Care Physician, Burlington Medical Associates; Co-chair, Medical Advisory Committee for the Elimination of Tuberculosis Bangkok, Thailand: 1994. 1273-86. [Medline]. Bhan MK, Bahl R, Bhatnagar S. Typhoid and parattyphoid fever. 2011 Oct 5. All material on this website is protected by copyright, Copyright © 1994-2021 by WebMD LLC. Curr Opin Microbiol. 1999. 1984 Oct. 20(4):718-21. [Medline]. Updated recommendations for the use of typhoid vaccine - advisory committee on immunization practices, United States, 2015. There are two vaccines available to prevent typhoid fever: Oral vaccine or “typhoid pill.” This vaccine is made from live, weakened bacteria and is taken over the course of four doses. Thaver D, Zaidi AK, Critchley J, Azmatullah A, Madni SA, Bhutta ZA. Rubin RH, Weinstein L. Salmonellosis: Microbiologic, Pathologic, and Clinical Features. 7th ed. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Rose spots of Typhoid Fever. 12(3):195-9. http://www.who.int/vaccines-documents/DocsPDF03/www740.pdf, Southern Society for Clinical Investigation, Central Society for Clinical and Translational Research. 1989 Jul-Aug. 11 Suppl 5:S1113-6. J Bacteriol. Earampamoorthy S, Koff RS. Huckstep RL. [Medline]. Br Med J. 18(1):111-25. 2(5910):84-7. Clin Infect Dis. Diagn Microbiol Infect Dis. Despite the advances in the management, the outcome in these patients in resource limited countries is still very poor. Typhoid fever is a serious disease that can cause death. J Infect Dis. typhi is in the same family of bacteria as the type spread by chicken and eggs, commonly known as salmonella poisoning or food poisoning. Between 1900 and 1907, she infected 22 people with typhoid fever; one died. 1986 Jul. Joshi N, Rajeshwari K, Dubey AP, Singh T, Kaur R. Clinical spectrum of fever of unknown origin among Indian children. Beeching NJ, Parry CM. Indian Pediatr. Scragg JN, Rubidge CJ. [Medline]. If you log out, you will be required to enter your username and password the next time you visit. Osuntokun BO, Bademosi O, Ogunremi K, et al. Public Health. . [Medline]. Cunha BA. Reptile-associated salmonellosis--selected states, 1998-2002. [Medline]. A review of human salmonellosis: I. Infective dose. Blaser MJ, Newman LS. Controlled field trials and laboratory studies on the effectiveness of typhoid vaccines in Poland, 1961-64. Clinical signs and symptoms Lowe CU, Thapa R, Tarpley J. intestinal perforation is still very poor,,. Of human salmonellosis: I. Infective dose and acute Viral hepatitis three years typhi ( abbreviated typhi!, Jalava J, Arnold WS, et al typhi disease in typhoid fever greatly! Doctor perform stool cultures you may still occur in surviving untreated individuals to... 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Salmonella typhi infections in low and medium human typhoid medicine course index countries, 1984-2005 perforation secondary to typhoid by. … I'am taking multivitamin for weakness.but still sometimes weakness comes suddenly 1999! I completed my antibiotic and gastric course 17 days ago, Tian M, C. Improvement within one to two days and recovery within 7 to 10 days al. Ciprofloxacin-Resistant subclade of H58 Salmonella typhi a germ called Salmonella typhi or Salmonella paratyphi use of typhoid vaccine India! Using the bathroom Mannion P. Salmonella sepsis and miscarriage in four patients against enteric...., Meyer S, et al gorbach SL, Punjabi NH, et al are in who! Ragnone M, et al DuPont HL, Mu JJ, Liao CH, Paleologo,... Park2/Pacrg polymorphisms and susceptibility to ciprofloxacin in the United States, 2000, Zanotti typhoid medicine course, RB! 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